Khavinson peptides in epigenetic control of ageing
The following text develops the hypotheses put forth more than a decade ago. The hypotheses relate to the tissue-specific effects of geroprotector short-chain peptides and to the epigenetic mechanism of these effects. Here, in section 2 and 4 respectively, we provide further evidence in favor of both hypotheses.
The opening section 1 outlines the general contours of the peptide-mediated regulation of physiological functions. In our opinion, this theme is now unduly overlooked. Section 3 presents some theory and calculations supporting the possibility of the direct interactions of short-chain peptides with DNA. Our studies have expanded the available evidence about the effects of peptides on such important functions as cell proliferation and tissue regeneration, inborn and acquired immunity, metabolic homeostasis, lipid peroxidation, antiradical defenses, and others.
The text is concluded with a compendium of data (sections 4 and 5), which suggest prospects for applying short-chain peptides in health care, from neurological to dermatological, with emphasis on retarding human ageing and increasing human lifespan.
We believe that Khavinson peptides® technology will be helpful in solving one of the main health-care problems of the XXI century: increasing the productive lifespan of humans.
1. REGULATORY PEPTIDES: THEIR PRODUCTION, TRANSPORT AND EFFECTS
1.1. Peptide-mediated regulation: key issues
1.2. Regulatory peptides synthesis
1.3. Regulatory peptides producers
1.4. Receptor mediated and non-receptor mediated interactions of peptides with their target cells
2. TISSUE-SPECIFIC EFFECTS OF PEPTIDES
2.1. Tissue-derived peptide preparations
2.2. Short-chain Khavinson peptides
3. THE MOLECULAR MECHANISMS OF PEPTIDE-DNA INTERACTIONS
3.1. Protein and peptide interactions with DNA
3.2. Modelling the interactions of short-chain peptides with DNA
4. PEPTIDES AS EPIGENETIC FACTORS
4.1. The epigenetic approach to ageing
4.2. The epigenetic effects of short-chain peptides on body organs
5. SHORT-CHAIN PEPTIDES AS MEDICINES: FINDINGS AND PROSPECTS
5.1. The central nervous system
5.2. Eye retina
5.3. The cardiovascular system
5.4. The respiratory system
5.5. The digestive system
5.6. Kidneys
5.7. The immune system
5.8. Carbohydrate metabolism
5.9. The musculoskeletal system
5.10. Ageing skin
5.11. Adaptation to high physical activity
